BioSPLASH is a suite of representative applications that we have assembled from the computational
biology community, where the codes are carefully selected to span a breadth of
algorithms and performance characteristics. The main results of this paper are the assembly
of a scalable bioinformatics workload with impact to the DARPA High Productivity
Computing Systems Program to develop revolutionarily-new economically-viable
high-performance computing systems, and analyses of the performance of
these codes for computationally demanding instances using the cycle-accurate IBM
MAMBO simulator and real performance monitoring on an Apple G5 system. Hence,
our work is novel in that it is one of the first efforts to incorporate life science application performance for optimizing high-end computer system architectures.
