David A. Bader
IEEE Fellow
AAAS Fellow
Professor
College of Computing
Georgia Tech
Atlanta, GA 30332


 
 

 

Fast Character Optimization in Parsimony Phylogeny Reconstruction

The problem of finding a phylogeny with maximum parsimony is one of the main problems in computational biology. While it is impossible to search the possible tree space exhaustively for large data sets, most heuristic approaches try to search in the neighborhood of sub-optimal trees. The speed of computing a score for each tree (e.g. tree length or total number of character changes) is as important as the different tree search strategies. Some techniques include short-cuts that have not been proven to be exact, and an incremental character optimization approach by which the speedup gains depends on data sets and is hardly analyzed in theory. This paper describes an exact and fast algorithm to compute tree length and our algorithm can obtain great speedup for any data sets. We discuss the algorithm for Fitch-parsimony, but it can also be applied to Wagner-parsimony.

Publication History

Versions of this paper appeared as:
  1. M. Yan and D.A. Bader, ``Fast Character Optimization in Parsimony Phylogeny Reconstruction,'' Technical Report, 2003.

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Last updated: July 25, 2004

 




Computational Biology



Parallel Computing



Combinatorics