The First Symposium on Machine Learning in Science and Engineering (MLSE’18), jointly organized by faculty from the Georgia Institute of Technology and Carnegie Mellon University, was held in Pittsburgh on June 6-8, 2018. Dana Randall, co-director of the Institute for Data Engineering and Science and Professor in the College of Computing at Georgia Tech, and Newell Washburn, Associate Professor in the Mellon College of Science at Carnegie Mellon University, served as co-chairs of the organizing committee. Randall and Washburn designed the new conference to bridge the diverse research areas that benefit from machine learning. Nearly 400 people attended, including over 40 from Georgia Tech. Among the attendees and session presenters were leaders in academia, government, and industry.